Alternative Medicine and Ankylosing Spondylitis (AS): A Comprehensive Review

 Why This Review Matters

The article emphasizes that while conventional therapies (NSAIDs, DMARDs, biologics) remain central to AS management, their side effects and high costs drive interest in complementary approaches. 

This review systematically explores how alternative medicine—particularly herbal and traditional therapies—may help regulate inflammation, oxidative stress, and abnormal bone formation.

Pathogenesis and Symptoms

• AS basics: An autoimmune disease causing chronic inflammation in the sacroiliac joints and spine.

• Symptoms: Back pain, morning stiffness, sacroiliitis, and extra-articular issues (like eye inflammation).

• Underlying mechanisms: Involves immune dysregulation, oxidative stress, and osteogenesis (new bone formation).

Diagnosis

• Clinical signs: Chronic back pain before age 45.

• Imaging: MRI and X-rays detect inflammation and joint changes.

• Lab markers: HLA-B27 is often present but not definitive.

Alternative Medicine Approaches Highlighted in the Review

The authors detail several complementary therapies:

• Herbal formulations: Plant-based decoctions and extracts that may reduce inflammation and regulate bone metabolism.

• Moxibustion: A heat-based therapy from traditional medicine, shown to relieve stiffness and pain.

• Acupuncture and Oriental medicine: Techniques that may improve mobility and reduce pain perception.

• Lifestyle integration: Exercise combined with herbal remedies enhances outcomes.

These therapies target key disease processes—immune imbalance, oxidative stress, and abnormal bone growth—suggesting a holistic benefit.

Evidence and Limitations

• Most findings come from cell and animal studies, with smaller clinical trials showing promise.

• Large-scale human studies are still needed to confirm safety and effectiveness.

• Alternative medicine should be used as complementary, not a replacement for conventional care.

Key Takeaways for People with AS

• Alternative medicine offers supportive options alongside standard treatments.

• Herbal remedies, moxibustion, and acupuncture may help manage pain and stiffness.

• Always consult your healthcare provider before starting new therapies.

• The future of AS management may lie in integrated approaches that combine modern medicine with traditional practices.

 You can read the full article here.