Thursday

Brain Fog and Celiac Disease

Brain Fog and Celiac Disease

An online survey indicates that brain fog and reduced cognitive function is real for many people with celiac disease. The most common words used by respondents to describe the symptoms were "difficulty concentrating," "forgetfulness," and "grogginess." While I do not have celiac disease I do experience these same symptoms from eating gluten so I was interested to share here what the survey discovered. 

This survey suggests that gluten-induced neurocognitive impairment (GINI) is common and may be severe in both individuals with CD and NCGS. Cognitive impairment and decline in physical functioning may be similar to that occurring in other illnesses, such as lupus. Clinical follow-up with both individuals with CD and NCGS should include assessment of GINI symptoms. Further research is warranted, including the development of a patient-reported outcome measure including neurocognitive effects of gluten exposure.

Goals: 

This study aimed to understand the neurocognitive symptoms associated with gluten exposure in individuals with self-reported celiac disease (CD) and nonceliac gluten sensitivity (NCGS).

Background: 

While gluten-induced neurocognitive impairment (GINI; eg, “celiac fog” or “brain fog”) is commonly described by individuals with CD and NCGS, there are little data regarding the prevalence and symptoms associated with these experiences.

Study: 

A 9-question online survey was accessed by 1396 individuals (1143 with CD; 253 with NCGS). Forced choice and free-response questions were asked of participants to obtain a description of neurocognitive symptoms experienced after gluten ingestion. Free-response answers were coded using a coding structure developed based on the Health-Related Quality of Life Instrument.

Results: 

The majority of survey participants (89% of CD and 95% of NCGS) reported having GINI symptoms. When describing symptoms, the most common word descriptors for both groups were difficulty concentrating, forgetfulness, and grogginess. Timing of symptoms, including onset and symptom peak, were similar across the 2 groups. Coding of free responses found the most common references were to cognitive, physical, psychological, and overall quality of life impacts.

My take on this study:

From reading this study I realise that what I have is probably nonceliac gluten sensitivity also called NCGS. I am not sure how this is diagnosed but I have mostly eaten gluten free for 26 years now. Sometimes there is a slip up when eating out or at a friend's house and very quickly I see the effects of the gluten. This is usually the next day with extreme brain fog which manifests in not being able to concentrate or take in information. As the survy found this does affect quality of life as you cannot function as you normally would on these days as you cannot even do your normal work. 


ORIGINAL ARTICLE: Gluten-induced Neurocognitive Impairment: Results of a Nationwide Study

Edwards George, Jessica B. PhD; Aideyan, Babatunde MA; Yates, Kayla BS; Voorhees, Kristin N. MA; O’Flynn, Jennifer PhD; Sweet, Kristen PhD; Avery, Kate MPH; Ehrlich, Alan MD; Bast, Alice BS; Leffler, Daniel A. MD,  MSJournal of Clinical Gastroenterology: May 28, 2021
doi: 10.1097/MCG.0000000000001561

Brain Fog and Celiac Disease

Monday

A promising path for future treatments to stop progressive multiple sclerosis

future treatments to stop progressive multiple sclerosis

Researchers at the National Institutes of Health, Johns Hopkins University, and others have published results of studies that map out the activity of genes, molecules, cells, and their interactions in specific types of multiple sclerosis (MS) brain lesions thought to contribute to progressive disability. The findings point to a possible informative new way to efficiently test the potential of therapies to stop nerve degeneration, and they identify culprits involved in tissue damage that might be targeted by new therapies in the future.

Tuesday

What can you eat on the elimination diet?

 Many people ask me what I eat on a daily basis when living with food reactions? So today I am answering that question in the hope that it can help many others understand how to simplify this process and find out what they can eat. 

What can you eat on the elimination diet?

Current and future therapies for primary Sjögren syndrome

This review summarizes the available evidence for systemic treatments for primary Sjögren syndrome (pSS) and includes discussions of advances in outcome assessment and promising future therapeutics.

Sjogren's syndrome medical review into future therapies

Monday

Type 1 Diabetes Study Points to New Treatments

 New research produces findings for a University of Virginia team studying Type 1 diabetes. 

CHARLOTTESVILLE – Scientists at the University of Virginia recently completed the largest and most diverse genetic study of type 1 diabetes ever undertaken.

Type 1 Diabetes Study Points to New Treatments: July 21 a vast study

Saturday

What are the RARE Autoimmune Diseases?

Today I will be explaining which autoimmune diseases fit into the category of rare and what does rare actually mean?

RARE Autoimmune Diseases

Friday

I have an autoimmune disease. Should I get a COVID - 19 vaccine?

Should I get a COVID - 19 vaccine if I have autoimmune diseases?

 “One concern is whether a vaccine can trigger a flare of autoimmune disease or cause autoimmune disease in someone who’s susceptible,” says Sarfaraz Hasni, MD, director of the Lupus Clinical Research Program at the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health in Bethesda, Maryland. 

Saturday

Risk of death among people with rare autoimmune diseases during COVID-19 pandemic

A study was done to quantify the risk of death among people with rare autoimmune rheumatic diseases (RAIRD) during the UK 2020 COVID-19 pandemic compared with the general population, and compared with their pre-COVID risk.  In this article, we explain the importance of this research.


Tuesday

Rituximab treatment for myasthenia gravis

Comparison between rituximab treatment for new-onset generalized myasthenia gravis and refractory generalized myasthenia gravis

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