Multiple sclerosis and Sjogren syndrome show more associations with Alzheimer disease compared with other autoimmune diseases.
Genetic liability to multiple sclerosis and Sjogren's syndrome may be related to the risk of developing Alzheimer disease, according to a study published in the Journal of Psychiatric Research.
Some evidence was found for liability to multiple sclerosis being associated with higher risk and liability to Sjogren's syndrome with lower risk of Alzheimer's disease. The researchers concluded:
Liability to multiple sclerosis and Sjogren's syndrome could be associated with Alzheimer's disease. The underlying mechanisms, such as the role of myelin and neuroinflammation, should be further investigated.
Yeung CHC, Yeung SLA, Schooling CM. Association of autoimmune diseases with Alzheimer’s disease: A mendelian randomization study. J Psychiatr Res. 2022;155:550-558. doi:10.1016/j.jpsychires.2022.09.052
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