Research from 2021 finds Vitamin D supplementation for five years taken with, or without, Omega 3 fatty acid may help reduce autoimmune disease.
In the randomized controlled trial 25,871 adults with autoimmune diseases, including rheumatoid arthritis, polymyalgia rheumatica, autoimmune thyroid disease, and psoriasis were divided into two groups. the first group was given Vitamin D and some received placebos. The second group was given fish oil and some received placebos. Both groups were monitored for just over five years. Vitamin D (2000 IU/day) or matched placebo, and omega 3 fatty acids (1000 mg/day) or matched placebo.
Autoimmune disease activity was reduced by 22% in those who took the increased levels of Vitamin D with or without fish oil. And those that only took fish oil supplements still saw a disease decline of 15%.
The study was done in the USA at a variety of participating hospitals and led by Dr. Karen Costenbader, MD, MPH, Lupus Foundation of America Medical-Scientific Advisory Council.
RESULTS:
This study of more than 25 000 older adults in the US provides evidence that daily supplementation with 2000 IU/day vitamin D or a combination of vitamin D and omega 3 fatty acids for five years reduces autoimmune disease incidence, with more pronounced effects found after two years of supplementation. Autoimmune diseases are a group of heterogeneous conditions with similar underlying pathogenetic mechanisms and together are associated with considerable morbidity and mortality. The clinical importance of these findings is high because these are well tolerated, non-toxic supplements, and other effective treatments to reduce the incidence of autoimmune diseases are lacking. Additionally, we saw consistent results across autoimmune diseases and increasing effects with time.
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