Autoimmune Research Roundup 2017

Hot Topics from 2017 were:

Vitamin D and Autoimmune diseases

The gut microbiome and responses in the immune system e.g.

• Immunological and clinical effect of diet modulation of the gut microbiome in multiple sclerosis patients: a pilot study 
• International study of the gut microbiome – the population of bacteria in the gut – in MS.  
• Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

Multiple Sclerosis

Systemic lupus erythematous

This is a roundup of recent research that has been done on Autoimmune diseases from around the world - all of them are from 2017. By no means is it a conclusive list. 

• McDonald Criteria Update: Further Distinction Between Relapsing-Remitting, Primary-Progressive MS 
• Anti-inflammatory antibodies may treat autoimmune disease: Enzyme treatment converts autoantibodies into anti-inflammatory antibodies in animal models of two autoimmune diseases 
• Hodgkin Lymphoma GWAS, Meta-Analysis Leads to Immune-Related Loci: overlap between its GWAS signals for classical Hodgkin lymphoma and loci implicated in MS, rheumatoid arthritis, systemic lupus erythematosus, primary biliary cirrhosis, ulcerative colitis, and celiac disease. 
• New study redefines Down syndrome as immune system disorder
• How T-cells navigate the rough-and-tumble environment of the bloodstream
• Technique Converts Harmful Autoantibodies into Anti-Inflammatory Antibodies In Vivo 
• Autoimmune Diseases and Oral Health: 30-Year Follow-Up of a Swedish Cohort 
• Resveratrol Role in Autoimmune Disease—A Mini-Review 
• Anorexia and Autoimmunity: Challenging the Etiologic Constructs of Disordered Eating 
• Scientists identify potential key to therapeutic treatments for autoimmune diseases 
• Autoimmune/inflammatory syndrome induced by adjuvants—ASIA—related to biomaterials: analysis of 45 cases and comprehensive review of the literature 
• Moving a Step Closer to Solving Problems of Autoimmune Disease and Transplant Rejection. Researchers at the Houston Methodist Research Institute report that they have identified a critical switch that controls T-cell function and dysfunction and have discovered a pathway to target it. 
• Azathioprine monotherapy in autoimmune blistering diseases: An option for mild to moderate cases 
• Research reveals new associations between type 1 diabetes and asthma in children. Finnish scientists have reported findings where a prior diagnosis of asthma was linked with an increased subsequent risk of type 1 diabetes by 41%. 
• Successful treatment of moderate-to-severe alopecia areata improves health-related quality of life. 
• Autoimmune nodo-paranodopathies of peripheral nerve: the concept is gaining ground: These patients have been classified up to now as chronic inflammatory demyelinating polyradiculoneuropathy CIDP 
• Cell Recycling Process Helps Trigger Immune Attack on Protective Nerve Cell Protein Myelin, MS, December 2017 
• Chronic fatigue is being addressed as a serious illness stemming from the autoimmune system’s reaction to infection or stress. December 2017 
• Ocular staining worse in dry eye patients with Sjögren’s syndrome, Dec 2017. 
• Diet quality is associated with disability and symptom severity in multiple sclerosis, Dec 2017. 
• Cell Recycling Process Helps Trigger Immune Attack on Protective Nerve Cell Protein Myelin. 
• Blood test for diagnosing multiple sclerosis that avoids the invasive, painful process of collecting fluid from the brain and spine. 
• Taurine, an amino acid, may boost the effectiveness of existing multiple sclerosis (MS) therapies, researchers say. 
• Cellular self-digestion process triggers autoimmune disease "This reactivation process is thought to play a decisive role in the development of autoimmune neuroinflammation." 
• Ultraviolet light offers MS relief
• ACR, EULAR release classification criteria for idiopathic inflammatory myopathies, Dec, 2017. 
• Systematic assessment and characterization of chronic pain in multiple sclerosis patients. 
• Autoimmune Neurology: A New, Rapidly Evolving Subspecialty 
• Changing gut bacteria in Crohn’s disease
• Improving walking for people with peripheral artery disease
• Immunotherapy, Gene Editing Advances Extend to Type 1 Diabetes
• Body’s Biological Clock and Time of Day Affects Immune Cells, Mouse Study Shows 
• Cellular self-digestion process triggers autoimmune disease 
• Orally Administered Calcitriol Reduced Inflammation in EB Mice: Lack of vitamin D is a potential key factor in epidermolysis bullosa acquisita (EBA) 
• Time of day affects severity of autoimmune disease: Immune responses and the regulation of autoimmunity are affected by the time of day when the response is activated. 
• Caplacizumab induces response in acquired thrombotic thrombocytopenic purpura. 
• Autoimmune conditions, infections common among diffuse large B-cell lymphoma survivors. 
• New phenome-wide association study offers insight into autoimmune diseases. 
• MAIT cells play a key role in onset of type 1 diabetes. A new study has highlighted the role mucosal-associated invariant T cells play in autoimmune diseases. 
• Autoimmune and infectious diseases among diffuse large b-cell lymphoma survivors.
• Teenage microbiome disruption linked to multiple sclerosis trigger: Mouse data 
• Risk factor for drug-induced skin disease identified - skin disease bullous pemphigoid (BP) in diabetic patients. 
• Throwing tomatoes at autoimmune diseases: William Langridge, PhD, is working on a new way to fight autoimmune diseases (AD) with edible vaccines. 
• Diet and lifestyle factors may trigger psoriasis: Environmental and lifestyle factors, may trigger onset of psoriasis and account for approximately 30% of the risk of the condition in people with a genetic preposition. 
• Newly ID’d Gene Variant Linked to Slower Progression of Systemic Sclerosis in Women in Small study. 
• Research underway for new type 1 diabetes treatment: Researchers at The University of Queensland are hoping a new form of immunotherapy could lead to better treatment. 
• Opdivo May Increase Risk for Autoimmune Disorders in Cancer Patients, Case Report Suggests. 
• First RNA-Based Blood Test to Identify IBS and IBD
• A low-gluten strain of wheat has been developed by scientists at the Institute of Sustainable Agriculture in Cordoba, Spain. December 2017. 
• High-throughput RNA sequencing reveals distinct gene signatures in active IgG4-related disease. December 2017. 
• Newly discovered drug-like compound may revolutionize treatment of autoimmune diseases. November 2017. 
• Researchers Find Gene Mutation That Makes Japanese More Susceptible to AAV a group of autoimmune diseases whose hallmark is inflammation that damages small blood vessels. 
• Arthritis, autoimmune disease discovery could lead to new treatments 
• A Large Order of Gut Microbes, Hold the Salt in autoimmune disease 
• Novel Compound Could Produce New Autoimmune Therapies
• Sodium intake may interact with genetics to increase latent autoimmune diabetes risk September 2017 
• Autoimmune Epilepsy: Current Research In Oxford. September 2017. 
• PTSD linked with increased Lupus risk September 2017. 
• Regular exercise, stress can both make a big difference in lupus, study finds: Daily activity appears to cut kidney damage from inflammation – and stress does opposite. September 2017. 
• Gates Foundation Invests $40 Million in Immunotherapy Collaboration 
• IBM to investigate role of microbiome in autoimmune disorders August 2017 
• Leaky Gut As a Danger Signal for Autoimmune Diseases 23 May 2017 
• HCDR1 Therapy Has Positive Impact on Sjogren Syndrome as Well as Lupus, Its Maker XTL Reports April 2017 
• How Autoantibodies Circumvent the Blood–Brain Barrier in Autoimmune Encephalitis April 2017 
• Sjogren's Syndrome Foundation's 2017 Sjogren's Treatment Guidelines, March 2017 
• Ectopic lymphoid neogenesis in rheumatic autoimmune diseases, Feb. 2017 affecting Rheumatoid arthritis, Sjogren's syndrome and Systemic lupus erythematous 

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