Personality, depression and anxiety in primary Sjogren's syndrome

Personality, depression and anxiety in primary Sjogren's syndrome
Personality, depression and anxiety in primary Sjogren's syndrome - Association with sociodemographic factors and comorbidity.

Mood, sleeping and several neuro-psychologic domains such as cognition are affected by pSS. Specifically, difficulties with attention, focusing, memory and new learning are commonly reported problems
Moreover, the personality traits of pSS patients can potentially interact with the subjective dryness symptoms and treatment outcome. Psychological factors may influence the ability of patients to cope with fatigue and its consequences including negative cognitions such as catastrophizing, avoidance of psychical activity and lack of social support or overprotection.


Patients with primary Sjögren's Syndrome (pSS) have diminished health quality and fatigue, arthralgia along with dryness of the mouth and eyes have major impact on their psychological and social aspects of life. 
The purpose of this study was to determine psychological features of patients with pSS. 
We analyzed personality, depression and anxiety of patients with primary Sjögren's Syndrome (pSS) in comparison with patients with rheumatoid arthritis (RA) and healthy controls (HC) and assessed their association with sociodemographic factors and comorbidity.


In 105 pSS patients (mean age 51.34 years, mean disease duration 5.98 years), 52 RA patients (mean age 51.37 years, mean disease duration 8.10 years) and 54 HC (mean age 51.35 years) clinical and sociodemographic characteristics were determined and results analyzed. 
At enrollment patients and controls completed the Revisited NEO Personality Inventory Five-Factor model (NEO-PI-R), the Zung Self-Rating Depression Scale and the Zung Self-Rating Anxiety Scale. Statistical analyses were performed using SPSS [Version 16.0]. The relative size of the effect was assessed based on standardized estimates of effect size (d).


Patients with pSS, similarly to RA patients had higher scores of Neuroticism and lower scores of Extraversion and Openness for experience  compared to HC. 
There was no significant differences between pSS group and HC in the depression. However, patients with pSS had higher anxiety in comparison to HC.

We confirmed that pSS patients have psychological profiles and levels of anxiety different to healthy subjects. 
In our study, patients with pSS were emotionally unstable, introverted, and more anxious than healthy controls. 
Education and satisfaction with family relationships were significant predictors for psychological characteristics of patients, independently of clinical diagnosis. 
The better understanding of personality dimensions in patients with pSS may provide adequate help by professionals in overcoming adaptation problems which have been observed in these patients.

See Full report on this study 


  1. Anonymous8:01 AM

    Hi! I've been following your site for a long time now and
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    a shout out from Porter Tx! Just wanted to say keep up the
    great job!

    1. Thanks to you and I'm glad you commented. Also it's great to know where readers are from. I live in Australia. Hi!

  2. Anonymous11:18 AM

    Now tell us something that we don’t already know.

    1. Yes a lot of the time I also think that research just tells us things that people with the condition could easily explain. On the other hand research is necessary to build up evidence, get more research and more treatments and hopefully a cure. We the people with the chronic illnesses are impatient though.

  3. Is PSS related to the MTHFR Mutation Gene?

  4. Do you know if PSS is related to the MTHFR Mutation Gene?

    1. The methylenetetrahydrofolate reductase (MTHFR) gene contains the DNA code to produce the MTHFR enzyme. This test detects two of the most common mutations.

      When there are mutations or variations in the MTHFR gene, it can lead to serious genetic disorders such as homocystinuria, anencephaly, spina bifida and others. The MTHFR enzyme is critical for metabolising one form of B vitamin, folate, into another. It is also part of the process that converts homocysteine into methionine, an important building block for many proteins.

    2. Primary Sjogren’s syndrome (pSS) confers increased risk for non-Hodgkin lymphoma (NHL) development. Two common polymorphisms, the c. 677C > T and c. 1298A > C, of the methylene-tetrahydrofolate reductase (MTHFR) gene,have been associated with susceptibility to NHL. So yes in a round about way PSS is related to the MTHFR Mutation Gene

    3. You may be interested in this scientific article

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