The autologous serum skin test is used as a screening test for chronic autoimmune urticaria and has a sensitivity and specificity of about 70 and 80%, respectively. The current gold standard diagnostic test is the basophil histamine release assay. NCBIAutoimmune urticaria (AIU) cannot be diagnosed by this test alone. A study has been done showing "A simple, combined test can improve the diagnosis of autoimmune urticaria."
Researchers from Hungary’s University of Debrecen have shown a more effective testing procedure for diagnosing AIU. The combination of tests have increased the sensitivity and specificity to 98% and 86%.
The researchers found that ASST positivity, the occurrence of symptoms at night, angioedema, incidence of more than five symptomatic days per week, and anti-thyroid antibody positivity were more frequent in the AIU group versus patients with chronic spontaneous non-AIU. These parameters were defined as specific to AIU. MD Magazine
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A strong connection has been found between AIU and the existence of other autoimmune diseases, such as rheumatoid arthritis, Sjögren's syndrome, Lupus (SLE) and celiac disease.