A U.K. study found that factors that associated with high levels of fatigue among patients with Sjogren's syndrome included pain, depression, and - unexpectedly - low levels of two proinflammatory cytokines. Proinflammatory cytokines are cytokines that promote systemic inflammation.
"This suggests that measures of disease activity in primary Sjogren's syndrome appear to be less important than cytokines, depression, and pain in accurately predicting fatigue levels," the researchers observed.
Conclusions: Cytokines, pain and depression appear to be the most powerful predictors of fatigue in Sjogren's Syndrome. The research data challenged the idea that proinflammatory cytokines directly cause fatigue in chronic immune conditions. "Instead, we hypothesise that mechanisms regulating inflammatory responses may be important."
Fatigue in primary Sjogren's syndrome is associated with lower levels of proinflammatory cytokines. Published in BMJ Journals in 19 July 2016